Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Foxa2  forkhead box A2   (Synonyms: Hnf3b, Hnf-3b, HNF3beta, HNF3-beta, Tcf3b, Tcf-3b)
Results	Reference
1	J:193837 Abdelhamed ZA, Wheway G, Szymanska K, Natarajan S, Toomes C, Inglehearn C, Johnson CA, Variable expressivity of ciliopathy neurological phenotypes that encompass Meckel-Gruber syndrome and Joubert syndrome is caused by complex de-regulated ciliogenesis, Shh and Wnt signalling defects. Hum Mol Genet. 2013 Apr 1;22(7):1358-72
1	J:333568 Akula SK, Marciano JH, Lim Y, Exposito-Alonso D, Hylton NK, Hwang GH, Neil JE, Dominado N, Bunton-Stasyshyn RK, Song JHT, Talukdar M, Schmid A, Teboul L, Mo A, Shin T, Finander B, Beck SG, Yeh RC, Otani A, Qian X, DeGennaro EM, Alkuraya FS, Maddirevula S, Cascino GD, Giannini C, Burrage LC, Rosenfield JA, Ketkar S, Clark GD, Bacino C, Lewis RA, Segal RA, Bazan JF, Smith KA, Golden JA, Cho G, Walsh CA, TMEM161B regulates cerebral cortical gyration, Sonic Hedgehog signaling, and ciliary structure in the developing central nervous system. Proc Natl Acad Sci U S A. 2023 Jan 24;120(4):e2209964120
1	J:207519 Anderegg A, Lin HP, Chen JA, Caronia-Brown G, Cherepanova N, Yun B, Joksimovic M, Rock J, Harfe BD, Johnson R, Awatramani R, An Lmx1b-miR135a2 regulatory circuit modulates Wnt1/Wnt signaling and determines the size of the midbrain dopaminergic progenitor pool. PLoS Genet. 2013 Dec;9(12):e1003973
1	J:301635 Bastidas-Ponce A, Roscioni SS, Burtscher I, Bader E, Sterr M, Bakhti M, Lickert H, Foxa2 and Pdx1 cooperatively regulate postnatal maturation of pancreatic beta-cells. Mol Metab. 2017 Jun;6(6):524-534
1	J:185651 Bluske KK, Vue TY, Kawakami Y, Taketo MM, Yoshikawa K, Johnson JE, Nakagawa Y, beta-Catenin signaling specifies progenitor cell identity in parallel with Shh signaling in the developing mammalian thalamus. Development. 2012 Aug;139(15):2692-702
1	J:175535 Deng Q, Andersson E, Hedlund E, Alekseenko Z, Coppola E, Panman L, Millonig JH, Brunet JF, Ericson J, Perlmann T, Specific and integrated roles of Lmx1a, Lmx1b and Phox2a in ventral midbrain development. Development. 2011 Aug;138(16):3399-408
1*	J:104803 Eggenschwiler JT, Bulgakov OV, Qin J, Li T, Anderson KV, Mouse Rab23 regulates Hedgehog signaling from Smoothened to Gli proteins. Dev Biol. 2006 Feb 1;290(1):1-12
1*	J:178498 Fagman H, Amendola E, Parrillo L, Zoppoli P, Marotta P, Scarfo M, De Luca P, de Carvalho DP, Ceccarelli M, De Felice M, Di Lauro R, Gene expression profiling at early organogenesis reveals both common and diverse mechanisms in foregut patterning. Dev Biol. 2011 Nov 15;359(2):163-75
1	J:124122 Ferri AL, Lin W, Mavromatakis YE, Wang JC, Sasaki H, Whitsett JA, Ang SL, Foxa1 and Foxa2 regulate multiple phases of midbrain dopaminergic neuron development in a dosage-dependent manner. Development. 2007 Aug;134(15):2761-9
1*	J:65599 Gaufo GO, Flodby P, Capecchi MR, Hoxb1 controls effectors of sonic hedgehog and mash1 signaling pathways. Development. 2000 Dec;127(24):5343-54
1	J:228881 Gazea M, Tasouri E, Tolve M, Bosch V, Kabanova A, Gojak C, Kurtulmus B, Novikov O, Spatz J, Pereira G, Hubner W, Brodski C, Tucker KL, Blaess S, Primary cilia are critical for Sonic hedgehog-mediated dopaminergic neurogenesis in the embryonic midbrain. Dev Biol. 2016 Jan 1;409(1):55-71
1*	J:262122 Gigante ED, Long AB, Ben-Ami J, Caspary T, Hypomorphic Smo mutant with inefficient ciliary enrichment disrupts the highest level of vertebrate Hedgehog response. Dev Biol. 2018 May 15;437(2):152-162
1*	J:98371 Gotz K, Briscoe J, Ruther U, Homozygous Ft embryos are affected in floor plate maintenance and ventral neural tube patterning. Dev Dyn. 2005 Jun;233(2):623-30
1	J:193109 Hayes L, Ralls S, Wang H, Ahn S, Duration of Shh signaling contributes to mDA neuron diversity. Dev Biol. 2013 Feb 1;374(1):115-26
1	J:128441 Jacob J, Ferri AL, Milton C, Prin F, Pla P, Lin W, Gavalas A, Ang SL, Briscoe J, Transcriptional repression coordinates the temporal switch from motor to serotonergic neurogenesis. Nat Neurosci. 2007 Nov;10(11):1433-9
1	J:152424 Jacob J, Storm R, Castro DS, Milton C, Pla P, Guillemot F, Birchmeier C, Briscoe J, Insm1 (IA-1) is an essential component of the regulatory network that specifies monoaminergic neuronal phenotypes in the vertebrate hindbrain. Development. 2009 Jul;136(14):2477-85
1	J:154668 Joksimovic M, Anderegg A, Roy A, Campochiaro L, Yun B, Kittappa R, McKay R, Awatramani R, Spatiotemporally separable Shh domains in the midbrain define distinct dopaminergic progenitor pools. Proc Natl Acad Sci U S A. 2009 Nov 10;106(45):19185-90
1	J:146200 Joksimovic M, Yun BA, Kittappa R, Anderegg AM, Chang WW, Taketo MM, McKay RD, Awatramani RB, Wnt antagonism of Shh facilitates midbrain floor plate neurogenesis. Nat Neurosci. 2009 Feb;12(2):125-31
1	J:310135 Kadoya M, Sasai N, Negative Regulation of mTOR Signaling Restricts Cell Proliferation in the Floor Plate. Front Neurosci. 2019;13:1022
1	J:130846 Kittappa R, Chang WW, Awatramani RB, McKay RD, The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age. PLoS Biol. 2007 Dec;5(12):e325
1	J:152413 Lin W, Metzakopian E, Mavromatakis YE, Gao N, Balaskas N, Sasaki H, Briscoe J, Whitsett JA, Goulding M, Kaestner KH, Ang SL, Foxa1 and Foxa2 function both upstream of and cooperatively with Lmx1a and Lmx1b in a feedforward loop promoting mesodiencephalic dopaminergic neuron development. Dev Biol. 2009 Sep 15;333(2):386-96
1	J:219800 Lungova V, Verheyden JM, Herriges J, Sun X, Thibeault SL, Ontogeny of the mouse vocal fold epithelium. Dev Biol. 2015 Mar 15;399(2):263-82
1	J:221299 Mansour AA, Khazanov-Zisman S, Netser Y, Klar A, Ben-Arie N, Nato3 plays an integral role in dorsoventral patterning of the spinal cord by segregating floor plate/p3 fates via Nkx2.2 suppression and Foxa2 maintenance. Development. 2014 Feb;141(3):574-84
1*	J:170258 Mavromatakis YE, Lin W, Metzakopian E, Ferri AL, Yan CH, Sasaki H, Whisett J, Ang SL, Foxa1 and Foxa2 positively and negatively regulate Shh signalling to specify ventral midbrain progenitor identity. Mech Dev. 2011 Jan-Feb;128(1-2):90-103
1	J:124115 Nakatani T, Minaki Y, Kumai M, Ono Y, Helt determines GABAergic over glutamatergic neuronal fate by repressing Ngn genes in the developing mesencephalon. Development. 2007 Aug;134(15):2783-93
1*	J:154096 Nelander J, Hebsgaard JB, Parmar M, Organization of the human embryonic ventral mesencephalon. Gene Expr Patterns. 2009 Dec;9(8):555-61
1	J:240032 Nouri N, Awatramani R, A novel floor plate boundary defined by adjacent En1 and Dbx1 microdomains distinguishes midbrain dopamine and hypothalamic neurons. Development. 2017 Mar 01;144(5):916-927
1	J:231849 Nouri N, Patel MJ, Joksimovic M, Poulin JF, Anderegg A, Taketo MM, Ma YC, Awatramani R, Excessive Wnt/beta-catenin signaling promotes midbrain floor plate neurogenesis, but results in vacillating dopamine progenitors. Mol Cell Neurosci. 2015 Sep;68:131-42
1	J:160534 Ono Y, Nakatani T, Minaki Y, Kumai M, The basic helix-loop-helix transcription factor Nato3 controls neurogenic activity in mesencephalic floor plate cells. Development. 2010 Jun;137(11):1897-906
1	J:80207 Persson M, Stamataki D, te Welscher P, Andersson E, Bose J, Ruther U, Ericson J, Briscoe J, Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity. Genes Dev. 2002 Nov 15;16(22):2865-78
1	J:192558 Rabe TI, Griesel G, Blanke S, Kispert A, Leitges M, van der Zwaag B, Burbach JP, Varoqueaux F, Mansouri A, The transcription factor Uncx4.1 acts in a short window of midbrain dopaminergic neuron differentiation. Neural Dev. 2012;7:39
1	J:331697 Ramachandran J, Zhou W, Bardenhagen AE, Nasr T, Yates ER, Zorn AM, Ji H, Vokes SA, Hedgehog regulation of epithelial cell state and morphogenesis in the larynx. Elife. 2022 Nov 18;11
1	J:188384 Rousso DL, Pearson CA, Gaber ZB, Miquelajauregui A, Li S, Portera-Cailliau C, Morrisey EE, Novitch BG, Foxp-mediated suppression of N-cadherin regulates neuroepithelial character and progenitor maintenance in the CNS. Neuron. 2012 Apr 26;74(2):314-30
1	J:213073 Runck LA, Method A, Bischoff A, Levitt M, Pena A, Collins MH, Gupta A, Shanmukhappa S, Wells JM, Guasch G, Defining the molecular pathologies in cloaca malformation: similarities between mouse and human. Dis Model Mech. 2014 Apr;7(4):483-93
1	J:243907 Snouffer A, Brown D, Lee H, Walsh J, Lupu F, Norman R, Lechtreck K, Ko HW, Eggenschwiler J, Cell Cycle-Related Kinase (CCRK) regulates ciliogenesis and Hedgehog signaling in mice. PLoS Genet. 2017 Aug;13(8):e1006912
1	J:239367 Stasiulewicz M, Gray SD, Mastromina I, Silva JC, Bjorklund M, Seymour PA, Booth D, Thompson C, Green RJ, Hall EA, Serup P, Dale JK, A conserved role for Notch signaling in priming the cellular response to Shh through ciliary localisation of the key Shh transducer Smo. Development. 2015 Jul 01;142(13):2291-303
1	J:63039 Sund NJ, Ang SL, Sackett SD, Shen W, Daigle N, Magnuson MA, Kaestner KH, Hepatocyte nuclear factor 3beta (Foxa2) is dispensable for maintaining the differentiated state of the adult hepatocyte. Mol Cell Biol. 2000 Jul;20(14):5175-83
1	J:199133 Tang M, Luo SX, Tang V, Huang EJ, Temporal and spatial requirements of Smoothened in ventral midbrain neuronal development. Neural Dev. 2013;8:8
1	J:231516 Trujillo-Paredes N, Valencia C, Guerrero-Flores G, Arzate DM, Baizabal JM, Guerra-Crespo M, Fuentes-Hernandez A, Zea-Armenta I, Covarrubias L, Regulation of differentiation flux by Notch signalling influences the number of dopaminergic neurons in the adult brain. Biol Open. 2016;5(3):336-47
1	J:215769 Wang DH, Tiwari A, Kim ME, Clemons NJ, Regmi NL, Hodges WA, Berman DM, Montgomery EA, Watkins DN, Zhang X, Zhang Q, Jie C, Spechler SJ, Souza RF, Hedgehog signaling regulates FOXA2 in esophageal embryogenesis and Barrett's metaplasia. J Clin Invest. 2014 Sep 2;124(9):3767-80
1	J:175801 Wang H, Lei Q, Oosterveen T, Ericson J, Matise MP, Tcf/Lef repressors differentially regulate Shh-Gli target gene activation thresholds to generate progenitor patterning in the developing CNS. Development. 2011 Sep;138(17):3711-21
1	J:279272 Wang JJ, Liu HX, Song L, Li HR, Yang YP, Zhang T, Jing Y, Isl-1 positive pharyngeal mesenchyme subpopulation and its role in the separation and remodeling of the aortic sac in embryonic mouse heart. Dev Dyn. 2019 Sep;248(9):771-783
1	J:79547 Watanabe T, Nakagawa K, Ohata S, Kitagawa D, Nishitai G, Seo J, Tanemura S, Shimizu N, Kishimoto H, Wada T, Aoki J, Arai H, Iwatsubo T, Mochita M, Watanabe T, Satake M, Ito Y, Matsuyama T, Mak T, Penninger J, Nishina H, Katada T, SEK1/MKK4-Mediated SAPK/JNK Signaling Participates in Embryonic Hepatoblast Proliferation via a Pathway Different from NF-kappaB-Induced Anti-Apoptosis. Dev Biol. 2002 Oct 15;250(2):332
1	J:142117 Wilson SI, Shafer B, Lee KJ, Dodd J, A molecular program for contralateral trajectory: Rig-1 control by LIM homeodomain transcription factors. Neuron. 2008 Aug 14;59(3):413-24
1	J:272890 Wu Z, Makihara S, Yam PT, Teo S, Renier N, Balekoglu N, Moreno-Bravo JA, Olsen O, Chedotal A, Charron F, Tessier-Lavigne M, Long-Range Guidance of Spinal Commissural Axons by Netrin1 and Sonic Hedgehog from Midline Floor Plate Cells. Neuron. 2019 Feb 20;101(4):635-647.e4
1	J:326661 Xu P, He H, Gao Q, Zhou Y, Wu Z, Zhang X, Sun L, Hu G, Guan Q, You Z, Zhang X, Zheng W, Xiong M, Chen Y, Human midbrain dopaminergic neuronal differentiation markers predict cell therapy outcomes in a Parkinson's disease model. J Clin Invest. 2022 Jul 15;132(14):e156768
1	J:232855 Yadav SP, Sharma NK, Liu C, Dong L, Li T, Swaroop A, Centrosomal protein CP110 controls maturation of the mother centriole during cilia biogenesis. Development. 2016 May 1;143(9):1491-501
1	J:194893 Yu K, McGlynn S, Matise MP, Floor plate-derived sonic hedgehog regulates glial and ependymal cell fates in the developing spinal cord. Development. 2013 Apr;140(7):1594-604